循环肿瘤细胞数量变化在预测局限性肾癌术后复发转移中的作用

陈涛; 李丽; 姚启盛; 李昊; 陈从波; 杨勇; 王黎

doi:10.3971/j.issn.1000-8578.2020.19.1236

循环肿瘤细胞数量变化在预测局限性肾癌术后复发转移中的作用

Effect of Change in Circulating Tumor Cell Counts in Predicting Postoperative Recurrence and Metastasis of Localized Renal Carcinoma

摘要

摘要:
目的探讨局限性肾癌患者行部分切除术后循环肿瘤细胞数量的变化在预测肿瘤复发转移中的作用。
方法收集41例局限性肾癌患者，依据术前及术后3月循环肿瘤细胞数量变化分为阳性组（n=23）和阴性组（n=18）。对两组患者进行随访，终点事件为肿瘤复发转移。对所得数据进行统计学分析。
结果阳性组复发转移率为43.5%，明显高于阴性组11.1%，差异有统计学意义（P=0.024）；阳性组5年生存率为58.0%，阴性组为88.9%，差异有统计学意义（P=0.048）。
结论术后3月循环肿瘤细胞计数较术前增加的局限性肾癌患者易出现复发转移。循环肿瘤细胞数量变化可作为较好的术后监测指标。

Abstract:
Objective To explore the role of the change in circulating tumor cell counts in predicting the recurrence and metastasis of localized renal cancer after partial nephrectomy.
Methods The included 41 patients were divided into positive(n=23) and negative(n=18) groups according to the counting changes of circulating tumor cells before and 3 months after surgery. All patients were followed up until tumor recurrence and metastasis. The data were statistically analyzed.
Results The recurrence and metastasis rate of the positive group was significantly higher than that of the negative group (43.5% vs. 11.1%, P=0.024). The 5-year survival rate was 58% in the positive group and 88.9% in the negative group (P=0.048).
Conclusion Recurrence and metastasis are more likely to occur in localized renal cancer patients with increased number of circulating tumor cells three months after surgery. The change of circulating tumor cell counts could be used as postoperative monitoring index.

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