Abstract: Breast cancer is the most common malignant tumor in women. Some studies have shown that elevated cholesterol level is associated with poor prognosis and increased risk of breast cancer, and cholesterol plays different roles in breast cancer with different molecular types. Statin, especially lipophilic statins, has a great role in reducing the risk of breast cancer and improving prognosis. This article reviews the role of cholesterol in the pathogenesis and progression of breast cancer, as well as the effect of lipid-lowering therapy on the recurrence and prognosis of breast cancer. It can provide more evidence for the basic research and clinical work of the relation between hypercholesterolemia and breast cancer.