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李娜, 周宝森, 李雪莲. 焦炉逸散物所致职业性肺癌死亡危险的Meta分析[J]. 肿瘤防治研究, 2019, 46(9): 835-840. DOI: 10.3971/j.issn.1000-8578.2019.18.1569
引用本文: 李娜, 周宝森, 李雪莲. 焦炉逸散物所致职业性肺癌死亡危险的Meta分析[J]. 肿瘤防治研究, 2019, 46(9): 835-840. DOI: 10.3971/j.issn.1000-8578.2019.18.1569
LI Na, ZHOU Baosen, LI Xuelian. Correlation Between Coke Oven Emissions and Death of Occupational Lung Cancer: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2019, 46(9): 835-840. DOI: 10.3971/j.issn.1000-8578.2019.18.1569
Citation: LI Na, ZHOU Baosen, LI Xuelian. Correlation Between Coke Oven Emissions and Death of Occupational Lung Cancer: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2019, 46(9): 835-840. DOI: 10.3971/j.issn.1000-8578.2019.18.1569

焦炉逸散物所致职业性肺癌死亡危险的Meta分析

Correlation Between Coke Oven Emissions and Death of Occupational Lung Cancer: A Meta-analysis

  • 摘要:
    目的 综合分析暴露焦炉逸散物与职业性肺癌死亡的关联性,为有效的干预措施和预防决策提供科学依据。
    方法 计算机检索PubMed、CNKI、VIP、Web of Science和万方数字化期刊全文数据库,筛选研究焦炉逸散物所致职业性肺癌的文献,并对其中的有效数据采用二分类变量的Meta分析,以死亡率的相对危险度(RR)为效应量,用软件Stata12.0进行统计分析。所有纳入的文献均进行质量评价。
    结果 共筛选出符合研究要求的文献9篇,其中英文文献4篇,中文文献5篇,且全部为队列研究。采用随机效应模型,得出分析结论。9篇文献合并后的相对危险度为2.24(95%CI: 1.75~2.87,Z=6.42, P < 0.05),即合并后结果的差异有统计学意义,表明合并后焦炉逸散物暴露组工人的肺癌死亡率高于对照组。用亚组分析处理异质性,发表年份、国家、随访年数、研究质量是异质性的主要来源。用漏斗图法、Begg秩相关法和Egger’s线性回归法检测发表偏倚发现本研究不存在发表偏倚,结果稳定。
    结论 焦炉逸散物所致职业性肺癌的死亡率高,对焦炉工应及早采取有效措施减少焦炉逸散物的暴露。

     

    Abstract:
    Objective To comprehensively analyze the correlation between coke oven emissions and death of occupational lung cancer, and provide scientific basis for effective intervention measures and prevention decisions.
    Methods The published articles on occupational lung cancer caused by coke oven emissions were searched from the PubMed, CNKI, VIP, Wanfang data and Web of Science databases. The effective data from these literatures was analyzed using a meta-analysis of binary variables with the relative risk of mortality (RR) as the effect size. Stata 12.0 software was used for statistic analysis.
    Results Nine literatures of cohort studies were involved, including four English literatures and five Chinese literatures. Using the random effect model, total relative risk effect size was 2.24(95%CI: 1.75-2.87, Z=6.42, P < 0.05), indicating that the mortality of workers in the group exposed to coke oven emissions was higher than that of the control group. In subgroup analysis, the published year, country, follow-up time and NOS score were the sources of heterogeneity. Funnel plot method, Begg method and Egger's method results showed that there was no publication bias in our research and the result was stable.
    Conclusion The mortality rate of occupational lung cancer caused by coke oven emissions is high, and coke oven workers should take effective measures to reduce the exposure of coke oven emissions.

     

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