Wnt信号通路与慢性粒细胞白血病

Wnt Signaling Pathway and Chronic Myelogenous Leukemia

摘要: 慢性粒细胞白血病作为血液系统的恶性增殖性肿瘤，其主要发病机制为BCR-ABL1融合基因形成，因此针对BCR-ABL1基因的靶向药物TKI为其治疗带来了希望，但TKI无法完全消除CML患者体内的LSCs，CML患者容易出现TKI药物耐药及治疗后复发。随着Wnt信号通路在实体瘤中的应用，大量研究发现Wnt信号通路同样在CML中起到重要作用，我们就Wnt信号通路对CML的影响作一综述。

Abstract: As a type of cancer that starts in certain blood-forming cells of the bone marrow, chronic myeloid leukemia (CML) is caused by the formation of an abnormal gene called BCR-ABL1. The targeted medicine TKI for BCR-ABL1 has great effect on treating CML: however, TKI is not able to completely remove the leukemia stem cells (LSCs) in CML patients, which will lead to drug resistance and leukemia relapse. With the application of Wnt signaling pathway in regulating stem cell function, many studies have found that it also plays an important role in treating CML. In this paper, we reviewed the impact of Wnt signaling pathway on CML therapy.