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蒋洪青, 刘平, 刘志惠. 三种方案治疗Ⅰb2、Ⅱa2期宫颈癌患者生存状况及术后并发症的比较[J]. 肿瘤防治研究, 2019, 46(9): 825-828. DOI: 10.3971/j.issn.1000-8578.2019.18.0605
引用本文: 蒋洪青, 刘平, 刘志惠. 三种方案治疗Ⅰb2、Ⅱa2期宫颈癌患者生存状况及术后并发症的比较[J]. 肿瘤防治研究, 2019, 46(9): 825-828. DOI: 10.3971/j.issn.1000-8578.2019.18.0605
JIANG Hongqing, LIU Ping, LIU Zhihui. Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens[J]. Cancer Research on Prevention and Treatment, 2019, 46(9): 825-828. DOI: 10.3971/j.issn.1000-8578.2019.18.0605
Citation: JIANG Hongqing, LIU Ping, LIU Zhihui. Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens[J]. Cancer Research on Prevention and Treatment, 2019, 46(9): 825-828. DOI: 10.3971/j.issn.1000-8578.2019.18.0605

三种方案治疗Ⅰb2、Ⅱa2期宫颈癌患者生存状况及术后并发症的比较

Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens

  • 摘要:
    目的 探讨单纯根治手术、新辅助化疗联合根治手术及同步放化疗联合根治手术方案对Ⅰb2、Ⅱa2期宫颈癌患者生存状况及术后并发症的影响。
    方法 回顾性分析140例Ⅰb2、Ⅱa2期宫颈癌患者临床资料,单纯根治手术治疗48例(A组),新辅助化疗联合根治手术治疗59例(B组),同步放化疗联合根治手术治疗33例(C组)。比较三组患者术中、术后临床指标、局部侵犯和淋巴结转移率、术后并发症发生率、中位总生存时间和术后1、2及3年生存率。
    结果 三组患者手术用时和总住院时间比较差异无统计学意义(P > 0.05);C组患者手术出血量、术后脉管和深肌层侵犯率及淋巴结转移率均显著低于A、B组(P < 0.05);三组患者术后神经侵犯率、术后并发症发生率、中位总生存时间和术后随访1、2及3年生存率比较差异均无统计学意义(P > 0.05)。B组按术前治疗方式又分为放疗组(28例)、化疗组(13例)和放化疗组(18例),放疗组3年生存率明显高于化疗组与放化疗组(P < 0.05)。
    结论 三组方案治疗Ⅰb2、Ⅱa2期宫颈癌生存状况和术后并发症风险相近;但同步放化疗联合根治手术有助于减轻手术创伤,降低术后局部侵犯和淋巴结转移率。

     

    Abstract:
    Objective To investigate the effects of radical surgery, neoadjuvant chemotherapy combined with radical surgery and concurrent chemoradiotherapy combined with radical surgery on the survival and postoperative complications of patients with stageⅠb2 andⅡa2 cervical cancer.
    Methods We retrospectively analyzed the clinical data of 140 patients with stageⅠb2 and Ⅱa2 cervical cancer, 48 patients were treated with radical surgery alone (group A), 59 patients were treated with neoadjuvant chemotherapy combined with radical surgery (group B) and 33 patients were treated with concurrent chemoradiotherapy combined with radical surgery (group C). The intraoperative and postoperative clinical indicators, local invasion and lymph node metastasis rate, postoperative complication rate, median overall survival, and 1-, 2-, and 3-year survival rates were compared among three groups.
    Results There was no significant difference in the time of surgery and total hospital stay among the three groups (P > 0.05). The bleeding volume, postoperative vessel and muscle invasion rate and lymph node metastasis rate in group C were significantly lower than those in group A and B (P < 0.05). Postoperative neurological invasion rate, postoperative complication rate, median overall survival and postoperative 1-, 2- and 3-year survival rates showed no significant difference among three groups (P > 0.05). Group B was divided into radiotherapy group (n=28), chemotherapy group (n=13) and chemoradiotherapy group (n=18) according to preoperative treatment. The 3-year survival rate of radiotherapy group was significantly higher than those of chemotherapy group and radiotherapy group (P < 0.05).
    Conclusion The patients with stageⅠb2 andⅡa2 cervical cancer in three groups have similar survival condition and postoperative complications. However, concurrent chemoradiotherapy combined with radical surgery could reduce the surgical trauma, local postoperative invasion and lymph node metastasis rate.

     

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