Abstract: Recently, the incidence and mortality of colorectal cancer in China have been increasing year by year. So nowadays, looking for an effective way to prevent, diagnose and treat early colorectal cancer has been the focus in the clinical and basic research of colorectal cancer. The body's normal cells are mainly oxidized by glucose, while the colorectal cancer cells have an obvious enhanced Embden-Meyerhof-Parnas that serves as a major source of energy. In this paper, the research progress and therapeutic strategies of glycolysis key enzyme, signal transduction pathway and transcription factor in the Embden-Meyerhof-Parnas of colorectal cancer are reviewed.