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杨立平, 李福兴, 李文贵. 68Ga-PSMA PET/CT在前列腺癌复发中的应用进展[J]. 肿瘤防治研究, 2018, 45(7): 505-509. DOI: 10.3971/j.issn.1000-8578.2018.17.1689
引用本文: 杨立平, 李福兴, 李文贵. 68Ga-PSMA PET/CT在前列腺癌复发中的应用进展[J]. 肿瘤防治研究, 2018, 45(7): 505-509. DOI: 10.3971/j.issn.1000-8578.2018.17.1689
YANG Liping, LI Fuxing, LI Wengui. Application Progress of 68Ga-PSMA PET/CT in Recurrent Prostate Cancer[J]. Cancer Research on Prevention and Treatment, 2018, 45(7): 505-509. DOI: 10.3971/j.issn.1000-8578.2018.17.1689
Citation: YANG Liping, LI Fuxing, LI Wengui. Application Progress of 68Ga-PSMA PET/CT in Recurrent Prostate Cancer[J]. Cancer Research on Prevention and Treatment, 2018, 45(7): 505-509. DOI: 10.3971/j.issn.1000-8578.2018.17.1689

68Ga-PSMA PET/CT在前列腺癌复发中的应用进展

Application Progress of 68Ga-PSMA PET/CT in Recurrent Prostate Cancer

  • 摘要: 前列腺癌(prostate cancer, PCa)发病率高,根治性治疗后,复发病灶的早期诊断对患者的预后至关重要。前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)是一种在PCa中高表达的跨膜糖蛋白,利用核素68Ga标记其小分子抑制剂作为显像剂,进行PET/CT显像,可以得到反映PCa病灶在体内分布的影像。欧美很多国家已经将68Ga-PSMA PET/CT应用于寻找PCa患者复发病灶,并取得了很好的效果,该技术在我国还处于起步阶段。本文综述了多个有关68Ga-PSMA PET/CT在前列腺癌复发中的研究进展,旨在提高我们对该项新技术的认识水平。

     

    Abstract: The morbidity of prostate cancer (PCa) is high. Early diagnosis of recurrence after primary treatment is very important for the prognosis. Prostate specific membrane antigen (PSMA) is a transmembrane glycoprotein, with high expression in PCa. Small molecule inhibitors of the PSMA is labeled by 68Ga(68Ga-PSMA). 68Ga-PSMA is used as imaging agent for PET/CT imaging. 68Ga-PSMA PET/CT can display the distribution of prostate cancer in vivo. Many European and American countries have used 68Ga-PSMA PET/CT to find recurrent lesions in prostate cancer patients and achieved good results. This technology is still in its initial stage in China. This article reviews the research progress of 68Ga-PSMA PET/CT in prostate cancer recurrence, in order to improve the understanding of this new technology in China.

     

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