肺腺癌中HLA-G的表达及其与患者预后的关系

张文龙; 张攀攀; 司加慧; 马媛媛; 杨跃

doi:10.3971/j.issn.1000-8578.2018.17.1594

肺腺癌中HLA-G的表达及其与患者预后的关系

HLA-G Expression in Lung Adenocarcinoma Tissues and Its Relationship with Prognosis

摘要

摘要:
目的探讨HLA-G在肺腺癌中的表达及其与患者预后的关系。
方法使用cBioPortal数据分析工具，分析HLA-G分子在肺癌中的表达；Kaplan-Meier Plotter数据库分析HLA-G分子在肺腺癌中的表达及与预后的关系；免疫组织化学法检测HLA-G蛋白分子在223例肺腺癌组织中的表达，分析其与临床病理特征的相关性。
结果 HLA-G基因的改变主要表现为扩增和错义突变，其中，扩增突变主要在肺腺癌中。HLA-G分子的表达与肺腺癌的预后呈负相关，HLA-G高表达组患者总生存期明显短于低表达患者。
结论 HLA-G分子在肺腺癌中高表达，在肺腺癌中是一种不良预后因素。

Abstract:
Objective To investigate the expression of HLA-G and determine the prognostic value of HLA-G for lung adenocarcinoma.
Methods The genomic alternation of HLA-G was analyzed using cBioPortal analytic tool. The expression of HLA-G was investigated immunohistochemically in 223 patients with lung adenocarcinoma. The correlation between HLA-G expression and clinicopathological features was analysed. The relationship between HLA-G expression and the survival rate of patients with lung adenocarcinoma was analyzed by Kaplan-Meier Plotter data.
Results HLA-G was mainly amplified in lung adenocarcinoma. Patients with low expression of HLA-G had longer overall survival than those with high HLA-G expression.
Conclusion HLA-G was found highly expressed in lung adenocarcinoma, and may serve as a prognostic factor and potential therapeutic target for lung adenocarcinoma.

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