黑色素瘤抗原泛素连接酶的研究进展
Research Progress on Melanoma-associated Antigen Gene-really Interesting New Gene (MAGE-RING) Ligases
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摘要: 黑色素瘤抗原（melanoma-associated antigen gene, MAGE）被视为一种肿瘤标志物和免疫治疗的热门对象。研究发现MAGE联合E3-RING泛素连接酶形成MAGE-RING连接酶复合体（MAGE-RING ligases, MRLs），成为泛素化的调控因子，从而调控连接酶的活性、底物的特异性和亚细胞定位。该文就MRLs的结构、活化机制和转录功能作一综述。Abstract: Melanoma-associated antigen gene(MAGE) is regarded as a popular target for cancer markers and immunotherapy. It was found that MAGE combined with E3-RING ubiquitin ligase to form MAGE-RING ligase complex(MRLs). MRLs are regulatory factors for ubiquitination to regulate the activity of the ligase, the specificity of the substrate and the subcellular localization. The structure, activation mechanism and transcription function of MRLs are reviewed in this article.
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