沙利度胺防治急性放射性直肠炎的临床观察

于娇; 雷雨; 靳荣辉; 陈鑫

doi:10.3971/j.issn.1000-8578.2017.05.008

沙利度胺防治急性放射性直肠炎的临床观察

Clinical Observation on Prevention and Treatment Effect of Thalidomide on Acute Radiation Proctitis

摘要

摘要:
目的探讨沙利度胺防治急性放射性直肠炎的疗效及对患者放疗期间生活质量的影响。
方法将90例行同步放化疗的宫颈癌根治术后患者随机分成两组：实验组（沙利度胺口服+同步放化疗）45例、对照组（同步放化疗）45例。观察两组急性放射性直肠炎的发生情况及KPS评分、睡眠、饮食及体重变化情况。
结果实验组急性放射性直肠炎级别明显低于对照组，肠炎首次发生时受照射剂量明显高于对照组，差异均具有统计学意义（均P < 0.05）。实验组患者的KPS评分改善率、睡眠改善率、饮食改善率、体重改善率均优于对照组，差异均有统计学意义（P < 0.05）。
结论沙利度胺防治急性放射性直肠炎安全、有效，并且可以改善患者放疗期间生活质量，保障放疗顺利进行。

Abstract:
Objective To explore the prevention and treatment effect of thalidomide on acute radiation proctitis, and the influence on the living quality of patients during radiotherapy.
Methods Ninety cervical cancer patients treated with concurrent chemoradiotherapy after surgery were divided randomly into two groups: 45 cases in the experimental group (thalidomide combined with concurrent chemoradiotherapy) and 45 cases in the control group (only concurrent chemoradiotherapy). The two groups were observed on the occurrence of acute radiation proctitis and the changes of Karnofsky score, sleep status, diet status and weight status.
Results The levels of acute radiation proctitis in the experimental group were lower than that in the control group with statistical significance (P < 0.05). The improvement rates of Karnofsky score, sleep status, diet status and weight status in the experimental group were all better than that in the control group (P < 0.05).
Conclusion Thalidomide, which can improve the living quality of patients during radiotherapy and guarantee radiotherapy process going smoothly, is a safe and effective method for the prevention and treatment of acute radiation proctitis.

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