Abstract: Endoplasmic reticulum stress/unfolded protein response is a new regulatory mechanism that promote tumor invasion. Moderate endoplasmic reticulum stress can not only protect the cells but also promote cell invasive. Many studies have shown that endoplasmic reticulum stress/unfolded proteins response is closely related to the development of tumor and can promote tumor invasion through regulate the expression of the Vascular endothelial growth factor (VEGF), glucose-regulated protein78(GRP78), anterior gradient 2(AGR2), promote the transformation of epithelial mesenchymal and degrade extracellular matrix. Understand the links between endoplasmic reticulum stress/unfolded protein response and tumor invasion may provide a new direction for tumor treatment. In this article, we will review summarize the current knowledge about the relevant mechanism of endoplasmic reticulum stress/unfolded proteins response promote tumor invasion.