KRT81 rs3660变异对肺癌发病风险的影响

杨振邦; 林佳; 曹蕾; 张艳艳; 郭锦翠; 牛泽人; 张雪梅

doi:10.3971/j.issn.1000-8578.2017.04.012

KRT81 rs3660变异对肺癌发病风险的影响

Effect of KRT81 rs3660 Polymorphism on Risk of Lung Cancer

摘要

摘要:
目的探讨KRT81基因3' UTR rs3660多态与肺癌遗传易感性之间的关系。
方法使用TaqMan-MGB荧光探针标记法对KRT81基因rs3660遗传变异进行基因分型。用Logistic回归计算rs3660各基因型影响非小细胞肺癌（NSCLC）和小细胞肺癌（SCLC）发病风险的OR值及95%CI。
结果 KRT81基因rs3660G＞C变异影响SCLC发病风险（P=0.048），但与NSCLC发病风险无关（P=0.614）。与rs3660GG基因型携带者相比，至少携带一个C等位基因者患SCLC风险显著降低（OR=0.70, 95%CI: 0.49~0.99）。吸烟分层分析显示，在不吸烟组中，至少携带一个C等位基因的非吸烟者具有较低的SCLC发病风险（OR=0.60, 95%CI: 0.36~0.99, P=0.049）。进一步以累计吸烟量来分析，未发现至少携带一个C等位基因的轻度吸烟者（或重度吸烟者）具有较低的SCLC发病风险（OR=0.61, 95%CI: 0.26~1.43, P=0.254）。
结论 KRT81基因rs3660G＞C变异影响SCLC发病风险，但与NSCLC发病风险无关。

Abstract:
Objective To explore the association of rs3660 polymorphism in the 3′UTR of KRT81 with the susceptibility for lung cancer.
Methods The genotypes of rs3660 were determined by TaqMan-MGB real-time PCR. The OR and 95%CI were estimated by Logistic regression to evaluate the association of rs3660 polymorphism with the risk of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).
Results KRT81 rs3660G > C variant affected the risk of SCLC (P=0.048), not NSCLC (P=0.614). When compared with the individuals with rs3660GG genotype, a significant decreased risk of developing SCLC was shown in C allele carriers (OR=0.70, 95%CI: 0.49-0.99). When stratified by smoking status, C allele carriers had significantly decreased risk among non-smokers (OR=0.60, 95%CI: 0.36-0.99, P=0.049). We also found that C allele carriers had no significantly decreased risk among light smokers (or heavy smokers) (OR=0.61, 95%CI: 0.26-1.43, P=0.254).
Conclusion KRT81 rs3660G > C polymorphism contributes to the risk of SCLC, not NSCLC.

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