胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响

刘蓉; 秦嶽

doi:10.3971/j.issn.1000-8578.2017.04.007

胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响

刘蓉,
秦嶽

Expression of IRSp53 in Epithelial Ovarian Carcinoma and Its Prognostic Significance

LIU Rong,
QIN Yue

摘要

摘要:
目的探讨胰岛素受体酪氨酸激酶底物p53蛋白（IRSp53）在上皮性卵巢癌（epithelial ovarian cancer, EOC）中的表达及其对患者预后的影响。
方法采用SP免疫组织化学法检测76例不同病理类型EOC组织中IRSp53蛋白的表达，分析其表达与患者的临床病理特征和病理分级的关系，探讨IRSp53对EOC患者预后的影响。
结果 IRSp53蛋白的表达与FIGO分期（Z=-3.526, P < 0.05）、组织病理分级（Z=-2.471, P < 0.05）、病理学类型（Z=-2.305, P < 0.05）、淋巴结转移（Z=1.124, P < 0.05）和CA125水平（Z=1.462, P < 0.05）显著相关。IRSp53的表达强度与病理分级之间呈显著正相关性（r=0.779, P < 0.05）。IRSp53蛋白低水平表达患者的5年累积生存率显著高于IRSp53蛋白高水平表达者（χ²=5.018, P < 0.05）。
结论 IRSp53蛋白可能是EOC发生发展过程中的关键调控因子，其过度表达导致患者的预后更差。

Abstract:
Objective To analyse the IRSp53 expression and its prognostic significance in epithelial ovarian carcinoma tissues.
Methods The expressions of IRSp53 in 76 cases of epithelial ovarian carcinoma were detected by SP immunohistochemical technique. The relationship between the IRSp53 expression and the clinical pathological characteristics and the pathological grading of the patients was analyzed. The prognostic significance of IRSp53 in epithelial ovarian carcinoma was discussed.
Results The expression of IRSp53 was significantly correlated with FIGO stage (Z=-3.526, P < 0.05), histopathological grading (Z=-2.471, P < 0.05), pathologic type (Z=-2.305, P < 0.05), lymph node metastasis (Z=1.124, P < 0.05) and CA125 level (Z=1.462, P < 0.05). There was a positive correlation between the expression intensity of IRSp53 and pathological grade (r=0.779, P < 0.05). The 5-year cumulative survival rate of the patients with low IRSp53 expression was significantly higher than that with high IRSp53 expression (χ² =5.018, P < 0.05).
Conclusion IRSp53 plays an important role in the development of epithelial ovarian carcinoma, and the over-expression of IRSp53 may lead to poor prognosis.

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