Objective  To investigate the expression of tandem leucine-rich repeats and immunoglobulin-like domains-1 (LRIG1) in human gastric adenocarcinoma tissues, and its relationship with clinicopathological parameters.

Methods  The immunohistochemical EnVision method was used to detect the expression of LRIG1 protein in 116 cases of gastric adenocarcinoma tissues and adjacent normal gastric tissues. The relationship between LRIG1 expression and clinicopathological parameter was analyzed.

Results  The positive rate of LRIG1 expression in gastric adenocarcinoma tissues (63.8%, 74/116) was significantly lower than that in the adjacent normal gastric tissues (81.9%, 95/116) , and the difference was statistically significant (P<0.05) . The expression of LRIG1 protein was closely related to tumor differentiation, depth of invasion, lymph node metastasis, distant metastasis and TNM staging (P<0.05) , but not to age, gender or tumor size (P>0.05) .

Conclusion  The expression of LRIG1 in gastric adenocarcinoma tissues is lower than that in the adjacent normal gastric tissues, and its expression is gradually decreased with the increased tumor malignant degree. LRIG1 may be involved in the tumorigenesis of gastric adenocarcinoma as a suppressor.