Abstract: Objective To evaluate the application of bipolar coagulation in hepatectomy with Glisson's pedicle transection method by comparing the efficacy of bipolar coagulation alone and classical clump crushing technique. Methods We collected clinical data of 101 primary hepatic carcinoma patients who received hepatectomy with Glisson's pedicle transection method. According to the use of bipolar coagulation, it was differed into bipolar coagulation alone group and clamp crushing technique group. Clinical details between two groups were compared. Results The two groups were similar in Child-Pugh classification, indocyanine green clearance rate at 15minutes(ICGR15), liver sclerosis, and operation time(P>0.05). There were significance differences in bleeding amount(488.89±268.76) vs. (390.00±209.82)ml, P=0.041, blood transfusion rate(25.92% vs. 8.51%, P=0.023), serum albumin in the first postoperative day(25.69±4.27) vs. (27.57±4.11)ml, P=0.026 and peritoneal drainage amount in 24h after operation60.00(10.00, 135.00) vs. 50.00(30.00, 80.00)ml P=0.039. Conclusion Compared with classical clump crushing technique, the application of bipolar coagulation in hepatectomy with Glisson's pedicle transection method is helpful in decreasing bleeding amount and blood transfusion rate, and patients have a higher serum albumin after operation.