Abstract: Hepatocyte growth factor receptor c-met and epithelial-mesenchymal transition(EMT) are closely related to the metastasis of colorectal cancer. Recent researches have found that the mechanism of c-met regulating EMT may play an important role in the process of invasion and metastasis of colorectal cancer, which becomes a new hot spot. Now we make a review on the new progress of the mechanism of c-met regulating EMT in colorectal cancer metastasis.