Abstract: Objective To investigate the expressions of vascular endothelial growth factor C(VEGF-C) and Podoplanin in rectum cancer tissues with lymph node metastasis in elder patients and their relationship with the prognosis. Methods VEGF-C and Podoplanin expressions in rectum carcinoma tissues and the corresponding lymph node metastasis carcinoma tissues in elder patients were detected by immunohistochemical method. At the same time the postoperative follow-up of these patients were analyzed. Results The expression rates of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis were higher than those in primary carcinoma tissues. The expressions of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis in elder patients were higher than those without lymph node(P<0.05). The levels of VEGF-C and Podoplanin and lymph node metastasis were the key factors to influence the prognosis of rectum cancer in elder patients. Conclusion VEGF-C and Podoplanin are highly expressed in rectum cancer tissues with lymph node metastasis in elder patients and related with the prognosis of rectum cancer. Their combination could be used as the index for the prognosis of rectum cancer with lymph node metastasis in elder patients.