Abstract: Objective To investigate the correlation between preoperative fibrinogen level and clinicopathological features of colon cancer. Methods We collected clinicopathological material and preoperative fibrinogen of 255 patients with colon cancer from June 2005 to June 2008 in The Affiliated Tumor Hospital of Xinjiang Medical University. Univariate and multivariate analysis were performed on the relationship between preoperative fibrinogen and clinicopathological features by t test and Logistic regression. Results Mean preoperative fibrinogen level of 255 patients with colon cancer was (3.17± 0.88) g/L. Univariate analysis showed that age, smoking, tumor size, tumor location, TNM stage, modify glasgow prognostic score(mGPS), WBC, neutrophil/lymphocyte ratio(NLR), platelet/lymphocyte ratio(PLR) and CEA were all associated with preoperative fibrinogen(P<0.05); meanwhile, there was no relationship between preoperative fibrinogen and nationality, grade, BMI, gross type, nerve/lymphatic invasion or serum AFP, respectively(P>0.05). Multivariate analysis showed that WBC (RR=4.08, 95.0%CI:2.07-8.04, P=0.00) and PLR(RR=1.79, 95.0%CI:1.02-3.14, P=0.04) were closely correlated with fibrinogen(P<0.05). Conclusion There are close correlation between preoperative fibrinogen level and age, smoking, tumor size, tumor location, TNM stage, mGPS score, WBC, NLR, PLR, CEA respectively in colon cancer patients. WBC and PLR may be independent risk factors for higher plasma fibrinogen, which could provide theoretical basis for reducing serum fibrinogen to correct hypercoagulable state and improve inflammatory microenvironment.