Abstract: Esophageal cancer is a common malignant tumor in China, and radiation therapy is one of the main means. Radioresistance is an important reason for the failure of radiation therapy and tumor local recurrence.All kinds of signaling pathways play an important role in the formation of esophageal cancer radioresistance.In this paper,we summarize the cell signal pathways of esophageal cancer radioresistance. Develop all kinds of effective antagonists of specific signaling pathways targets could provide early interventions to esophageal cancer and other cancers.