神经菌毛素促进VEGF介导的血管生成作用及其机制研究进展

Research Progression on Angiogenesis Effect and Mechanism of VEGF Promoted by NRP-1

摘要: 神经菌毛素（neuropilin-1, NRP-1）作为NRP家族中重要成员之一，常表达于内皮细胞及一些肿瘤细胞，是信号素（Sema 3A）??血管内皮生长因子(VEGF)??血小板源性生长因子（PDGF）等相关因子的共受体。因此，它在神经轴突的生长、血管的生成发育和肿瘤生长转移中起重要作用。而血管内皮生长因子（VEGF）作为重要的血管生成调节因子，同样在促进肿瘤血管形成，发生及发展中发挥着重要作用。近年来越来越多研究证实NRP-1可以促进VEGF介导的血管形成，进而促进肿瘤发生发展。本文就近年来NRP-1促进VEGF血管形成作用及机制作一综述。

Abstract: Neuropilin-1(NRP-1), acted as one important member of NRP family,expressed in endothelial cells and certain tumour cells and conducted common receptor of Sema 3A,VEGF,PDGF and TGF. Therefore, it plays an important role in axon growth,angiogenesis and tumor growth. VEGF acts as one important regulating factor in angiogenesis, also played an important role in tumor angiogenesis, growth and development. More and more researches had confi rmed that VEGF could facilitate angiogenesis, tumor growth and development as combined with NRP-1. This article mainly summarizes angiogenesis and mechanism of VEGF promoted by NRP-1.