Abstract: Objective To explore the association between 8q24 rs13281615 single nucleotide polymorphism and risk of breast cancer (BC). Methods PubMed, EMBASE and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Odds ratios (ORs) with 95% confi dence intervals (CIs) were used to assess the strength of the association. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots. Results Fourteen studies were included in the meta-analysis, including 44,283 cases (5170 Chinese and 39113 mixed) and 55756 controls (5589 Chinese and 50167 mixed). The 8q24 rs13281615 SNP GG genotype was significantly associated with increasing risk of BC (GG vs. AG+AA, OR=1.13, 95%CI:1.08-1.19, P<0.000), while AA genotype was signifi cantly associated with lower risk of BC (AA vs. AG+GG, OR=0.89, 95%CI:0.84-0.93, P<0.000). Conclusion The 8q24 rs13281615 GG genotype is a risk factor for developing BC, while AA genotype is a protect factor.