Abstract: Objective To assess the therapeutic effect of two different approaches of neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer patients. Methods We searched the MEDLINE, Chinese Journal Full-text Database (CNKI) and WanFang Database, and then took a quadratic search on the references, retrieval time was before July 2012，we run a quality assessment and Meta-analysis on the randomized controlled trials which met the inclusion criteria. Results Twelve researches of 765 patients were met the criterion ultimately, including 389 cases of intra-arterial chemoembolization group (arterial group) and 376 cases of intra-venous chemotharopy group (venous group). Meta-analysis results showed that the complete remission rate and total efficiency were greater in arterial one than in the intravenous group, the differences in efficacy were statistically significant. Vasclar invasion，lymph node metastasis and parametrial infiltration in artery group were less than in vein group, with statistically significant, whereas the partial remission rate showed no difference between two approaches. Conclusion Considering the therapeutic effect, safety and poor prognosis factors, patients with locally advanced cervical carcinoma may be more easily benefit from intra-arterial chemoembolization pathway.