TRAIL及其受体在乳腺癌组织中的表达及意义

Expression and Significance of TRAIL and Its Receptors in Breast Cancer

摘要: 目的探讨肿瘤坏死因子相关凋亡诱导配体（TRAIL）及其受体（DR4、DR5、DcR1、DcR2）在乳腺癌组织的表达及意义。方法用反转录聚合酶链反应（RT-PCR）法检测60例乳腺癌及对应的正常乳腺组织中TRAIL及其受体的表达。结果乳腺癌组织中TRAIL、DcR1、DcR2表达均低于正常乳腺组织(P＜0.05)，且TRAIL及其受体的表达与乳腺癌的分期、分级等无关(P＞0.05)。结论 TRAIL及其受体在乳腺癌凋亡过程中起着重要的作用，TRAIL及其诱骗受体低表达同乳腺癌的发生关系密切。

Abstract: Objective To study the expression and receptors（DR4，DR5，DcR1，DcR2） of TRAIL in breast cancer tissues. Methods Expression of TRAIL and its receptors（DR4，DR5，DcR1，DcR2）were assayed by reverse transcriptase polymerase chain reaction(RT-PCR） in 60 breast cancer tissues and corresponding normal breast tissues. Results The expression of TRAIL and its receptors（DcR1，DcR2）were lower in breast cancer tissues than those of normal breast tissues (P＜0.05).The expression of TRAIL and its receptors（DR4，DR5，DcR1，DcR2）showed no correlations to the tumor grade and clinical stage (P＞0.05). Conclusion TRAIL and its receptors play an important role in the apoptosis of breast cancer.The low expression of TRAIL and the loss of the decoy receptors（DcR1，DcR2）in breast cancer may be concerned significantly with its pathogenesis.