Abstract: Objective To investigate the distribution of different molecular subtypes of invasive ductal carcinoma of breast(IDC)，and analyze the correlation between molecular subtypes and clinical features. Methods A total of 100 patients with IDC from January 2006 to June 2011 were classified into four different subtypes according to estrogen receptor (ER), progestogen receptor (PR) and epidermal growth factor-2 (HER-2)，and analyze their relation to the clinical features of IDC. Results Among all 100 cases,Luminal A subtype was the majority (65％), triple negative was the second largest group(17% ), and Her-2 enriched and Luminal B type are the smallest groupes (17% and 7%, respectively). The ages of patients of IDC subtype were mainly between 40 and 59 (73%).The ages of patients of Luminal A subtype were mainly between 40 and 49.The ages of the patients of the other three molecular subtypes were mainly between 50 and 59(P<0.05) . The distributions in different age groups had statistic significance (P<0.05). There were more lymph nodes metastasis in Luminal B(71.4%) and HER-2 enriched (63.6%) groups(P＜0.05) than in Luminal A group(30.1%). The axillary lymph nodes metastasis rates of different molecular subtypes varied significantly (P<0.05). As for histopathologic grading,Luminal A patients were mainly gradeⅠ, and most Triple Negative patients were grade Ⅲ（P＜0.05）. The difference had statistic significance (P<0.05). Conclusion The distributions of different molecular subtypes of IDC has significant difference．The molecular subtypes are related to the clinical features of IDC.