Abstract: Objective To study the effects of Scorpid poison in combination with Paclitaxe on inhibiting transplanted gastric cancer in the nude mice. Methods Model of nude mice subcutaneous transplant tumor of human gastric cancer cells was established．Serum VEGF concentration was determined with ELISA test．The weight of tumor and tumor suppressor rate were recorded．Flow cytometry detected cell apoptosis rate,TUNEL method was used to detect the tumor cell apoptosis index(AI).Pathology detection of liver,kidney and lung of nude mice. Results The weight of tumors and serum VEGF concentration in combined treatment group were obviously decreased than the control group and the single treatment group ( P<0.05).Apoptosis rate in combined treatment group was obviously improved than the control group and the single treatment group (P<0.05). The apoptosis index in combined treatment group was higher than the control group and single group (P<0.05).There is no significant abnormal situation about using scorpid poison,paclitaxe,or both the two in pathology detection of liver,kidney and lung of nude mice. ConclusionThe inhibition effect of the combination of Scorpid poison and Paclitaxe on the gastric carcinoma in nude mice was significantly superior than that of separated use. Pathology tests showed no obvious effects on nude mouse liver,kidney and lung under the concentration of Scorpid poison and paclitaxel used in this study.