Abstract: Objective To explore the effects of two different therapy programs on prognosis of invasive bladder cancer patients. Methods Related papers in Medline,Chinese Biological Medicine Database,China Journal Fulltext Database and China Scientific Journal Database were searched,then these papers were assessed,and the 5-year survival rates of invasive bladder cancer patients after receiving bladder preserving resection plus systemic chemotherapy or radical cystectomy were analyzed by using Meta analysis. Results The test statistics was Z=1.22,P=0.22,it was considered as “nonsignificant” result at the 5% level according to its P-value. Conclusion There is a no difference between bladder preserving resection plus systemic chemotherapy and radical cystectomy for invasive bladder cancer patients,and choosing a bladder reservation program modestly may be helpful for improve the patients′ living quality.