DICER基因多态性与食管癌淋巴结转移危险因素的关系

doi:10.3971/j.issn.1000-8578.2012.07.014

DICER基因多态性与食管癌淋巴结转移危险因素的关系

Association of Variant Allele of DICER and Decreased Risk of Esophageal Cancer Lymph Node Metastasis

摘要

摘要: 目的探讨中国汉族人群中DICER基因rs3742330多态性与食管癌淋巴结转移危险因素的关系。方法采用以医院为基础的病例-病例研究方法，采用基质辅助激光解析电离飞行时间质谱(MALDI-TOF MS)技术分析85例有淋巴结转移的食管癌和270例无淋巴结转移的食管癌DICER基因rs3742330基因多态性，计算各种基因型与食管癌淋巴结转移的发生风险及其95%可信区间。结果DICER rs3742330 A>G多态三种基因型AA、AG、GG在食管癌淋巴结转移组的频率分别为31.76%、61.18%、7.06%，在无淋巴结转移组的频率分别为34.44%、48.15%、17.41%，与携带DICER rs3742330 AA基因型的个体相比较，DICER rs3742330 GG基因型显著减少食管癌淋巴结转移发生的危险。结论DICER rs3742330 A>G基因多态性可能是食管癌淋巴结转移的保护性因素。

Abstract: Objective To investigate the relationship between DICER polymorphism and the susceptibility to lymph node metastasis in esophageal cancer in Chinese Han population. Methods Genotypes were determined by matrix-assisted laser desorption /ionization time-of-flight mass spectrometry (MALDI-TOF MS) method in 85 lymph node metastasis positive patients and 270 lymph node metastasis negative patients. Results The DICER rs3742330 A>G genotype frequencies were 31.76%(AA),61.18%(AG),7.06%(GG) in the lymph node positive group and 34.44%(AA),48.15%(AG),17.41%(GG) in the lymph node negative group,respectively.Logistic regression analyses revealed that the risk associated with DICER rs3742330 GG genotype was 0.36 (95%CI=0.15~0.88) which was much lower than DICER rs3742330 AA+AG genotype. Conclusion DICER rs3742330 A>G polymorphism may be a protective factor of lymph node metastasis.

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