Abstract: Objective To establish the overall diagnostic accuracy of the measurements of serum squamous cell carcinoma antigen (SCC-Ag) for lymph node metastasis（LNM） in squamous cell cervical cancer. Methods After a systematic review of current studies,we pooled the sensitivity,specificity of serum SCC-Ag in diagnosis LNM cases from cervical cancer patient using random effects models.Qualified studies were retrieved from The Cochrane Library,Cochrane Central Register of Controlled Trials,Pubmed,Embase,CNKI，WanFang，and CBM database.Two reviewers independently assessed the methodological quality of each study with the tool of QUADAS.We drew the Summary Receiver Operating Characteristic (SROC) curve、funnel figure of the included studies and made Meta-analyses using Meta-Disc 1.4 and Stata 11.0 software. Results Ten studies met the inclusion criteria for the analysis.After testing the heterogeneity of the included studies,a random effect model was selected to calculate the pool weighted sensitivity and specificity with 95% confidence interval:the sensitivity was 60%［95%CI（0.54~0.65）］,the specificity was76%［95%CI（0.73~0.78）］,the DOR was 5.38［95%CI（3.27~8.87）］,and the AUC of SROC was 0.7126（unsatisfied）.The sources of heterogeneity maybe according to the cutoff. Conclusion SCC-Ag has certain diagnosis value in LNM cases，but it is not a perfect index to identify LNM cases from cervical cancer patients.