Abstract: Objective To explore the curative effect of neoadjuvant chemotherapy for stage ⅠB2~ⅡB cervical cancer. Methods Forty-four cases of stage ⅠB2~ⅡB cervical cancer treated by neoadjuvant chemotherapy(NACT) + surgery + radiotherapy,and 52 cases of stage ⅠB2~ⅡB treated by surgery + radiotherapy from January 2001 to November 2005 were retrospectively analyzed. Results In 44 patients of NACT,CR,PR,SD and PD were 6 cases (13.64%),21 cases (47.73%),13 cases (29.55%) and 4 cases (9.09%),respectively.Total effective rate was 61.36% (27/44).Toxicities including bone marrow suppression,gastrointestinal toxicity and hair loss,were tolerable and did not effect the surgery.All 96 cases were pathologically examined after surgery.In the treatment group，the prevalence rates of positive margins and positive pelvic lymph nodes were 2 (4.55%) and 7 patients (15.91%) and lower than those in the control group 14 cases (26.92%) and 20 patients (38.46%),respectively,P<0.05).In the treatment group,3 years and 5 year survival time were 93.18% (41/44) and 86.36% (38/44) and increased than those in the control group( 86.54% and 67.31%,P<0.05). Conclusion Neoadjuvant chemotherapy could improve the prognosis of stage ⅠB2~ⅡB cervical cancer.