Abstract: Objective To investigate the effects of Jinmi decoction on the serum vascular endothelial growth factor(VEGF) in non-small cell lung cancer and its anti-tumor mechanism. Methods Sixty cases of non-small cell lung cancer were randomly divided into combination therapy group(Jinmi decoction + chemotherapy) and chemotherapy group.The serum VEGF concentration was detected by ELISA in the two groups and in 20 normal controls. Results The serum VEGF concentration in non-small cell lung cancer was(389.45± 80.23)pg/ml,higher than that in normal controls(P<0.01).The concentration of serum VEGF after therapy in combination therapy group was significantly lower than that in chemotherapy group(231.52 ±83.91)pg/ml vs..(295.17±76.43)pg/ml,(P<0.05). Conclusion Jinmi decoction could obviously reduce the concentration of serum VEGF and inhibit tumor angiogenesis in non-small cell lung cancer.