Abstract: Objective To investigate the clinical pathological characteristics,survival and prognostic factors of patients with triple negative breast cancer. Methods The clinical and pathological data of 560 patients,confirmed as breast cancer in Zhongnan hospital of Wuhan university and hubei cancer hospital from Jan 2004 to Dec 2009,were collected.We analyzed the clinical characteristics,recurrence rate and survival rate of the triple-negative breast cancer(TNBC) patients by comparing the characteristics between the two groups(TNBC and non-TNBC groups). Results Compared with non-TNBC group,the patients of TNBC group were usually young,associated with large masses,high histological grade and lymph node metastasis.There were significant differences in median survival time and the 5-year disease-free rate between TNBC group and non-TNBC group.Tumor mass,lymph node metastasis and menopause were important prognostic factors. Conclusion Triple negative breast cancer is one subtype of breast cancer with poor prognosis.