Abstract: Objective To evaluate the relationship between polymorphism of p73 4G14C-4A14T and susceptibility to colorectal cancer. Methods Studies from 2000—2010 were retrieved through Cochrane Library,Medline,Elsevier,Ovid,Highwire Press,PubMed，web of science，BIOSIS Preview，Journal Citation Reports，FMJS and EMMC database without language limitation to collect relevant papers.Odds ratio of p73 4G14C-4A14T genotype distributions in the group of patients with colorectal cancer and the group of healthy control was calculated.The Meta-analysis was applied with RevMan 5.0 software for Heterogeneity test and pooled OR calculation.Result Five case-control studies with 919 cases and 1234 controls were analyzed by fixed effects model(FEM) meta-analysis method.The pooled Odds Ratio of p734G14C-4A14T genotype GC/GC vs.GC/AT+AT/AT was 0.84(95%CI:0.71~1.00),Z statistics were 1.95,GC/GC vs.AT/AT was 0.50(95%CI:0.35~0.70),Z statistics were 4.00.AT/AT vs.GC/GC+GC/AT was 1.94 (95%CI:1.39~2.70)，Z statistics were 3.91. Conclusion We found that the variant AT/AT homozygote was associated with a significantly increase risk of colorectal cancer.There was enough evidence currently to prove that there was a relationship between p73 4G14C-4A14T genetic polymorphism and susceptibility to colorectal cancer.It was demonstrated that the genetic polymorphism of p73 4G14C-4A14T was an important risk factor for susceptibility to human colorectal cancer.