M2型肿瘤相关巨噬细胞在胰腺癌中的表达及其临床意义

doi:10.3971/j.issn.1000-8578.2012.01.015

M2型肿瘤相关巨噬细胞在胰腺癌中的表达及其临床意义

Expression and Clinical Significance of M2 Tumor-associated Macrophage in Pancreatic Carcinoma

摘要

摘要: 目的探讨CD68、CD163标记的M2型肿瘤相关巨噬细胞（Tumor-associated macrophage,TAM）在胰腺癌中的表达及其临床意义。方法应用免疫组织化学检测CD68、CD163蛋白在50例胰腺导管腺癌中的表达；分析它们与临床病理特征之间的关系。结果CD68、CD163阳性表达率分别为84%和76%；它们与癌细胞同时聚集在癌侵袭边缘、血管、淋巴管、神经周围；CD68、CD163阳性表达与患者年龄、性别、肿瘤部位、病理分级无关（P>0.05），与肿瘤大小、淋巴结转移、血管侵犯和临床分期密切相关（P<0.05）。结论M2型肿瘤相关巨噬细胞在胰腺癌中广泛浸润，它可能促进了胰腺癌的恶性进展。

Abstract: Objective To investigate the expression of M2 tumor-associated macrophage in pancreatic cancer and its clinical significance. Methods The proteins of CD68 and CD163 in 50 cases of pancreatic carcinoma were detected with immunohistochemical staining,and the relationship between CD68 or CD163 and clinicopathological features of pancreatic cancer were analyzed. Results Proteins expression of CD68 and CD163 in pancreatic cancer tissues were 84% and 76%,respectively.There was no significant correlation between the expression of CD68 or CD163 protein with the age,gender，tumor location and the degree of differentiation in patients with pancreatic cancer(P>0.05).However,there was significant correlation between the expression of CD68 or CD163 protein with tumor size,lymph node metastasis,venous invasion and clinical staging (P<0.05). Conclusion M2 tumor-associated macrophage is wide infiltration expressed in pancreatic cancer,and it may promote the development of pancreatic cancer.

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