Abstract: ObjectiveTo observe the availability and the safety of the therapy using Irinotecan combined with continuous infusion of tegafur in advanced colorectal cancer.MethodA total of 53 patients were given chemotherapy regimen.That's 150 to 180mg per square meter of Irinotecan parenteral solution,i.v.on day 1 and fuorouracil 200 mg/m2 and Tagafur 2000 mg/m2 civ.48h,on day 1 and day 2.Reiterature per 2 w.To evaluate the near future therapeutic effect according to the RECIST standard and to evaluate the toxic reaction according to the NCI-CTC standard 2w later.ResultAll patients had total accepted 432 chemotherapy cycles.There 4 to 14 cycles for one patient and the average was 8.2 cycles for one patient.Fifty-one of the patients′ recent therapentic efficacy could be evaluated,and 53 of the patients′ toxic reaction could be evaluated.The overall response rate (RR) was 27.5%,and the disease control rate (DCR) was 66.7%.Three of these gained clinic completed relief,and 11 of these gained partial relief.The TTP was 6.5 m,the common toxic reaction was Leucopenia 43.4%（3.8% in grade Ⅲ） and diarrhea 20.8% . Conclusion The chemotherapy regimen with a combination of Irinotecan and fuorouracil had indeed better therapeutic effect,moreover the toxic reaction was tolerant,reversible and easy to handle,which shows more potential clinic applications.