Abstract: ObjectiveTo imestigate the expressions of YAP and p73 and their clinical significance in breast carcinoma. Methods The expressions of YAP and p73 in 60 cases of breast carcinoma tissue and 26 cases of normal breast tissue adjacent to breast carcinoma were detected by immunohistochemistry,and the relationship of the expressions of YAP and p73 to clinical and pathological features of breast cancer was analyzed. Results The expression of YAP was significantly higher in normal breast tissue adjacent to breast carcinoma than that of in breast carcinoma tissue,suggesting YAP gene deletion may be involved in the formation of breast cancer;The weakly or negative expression of p73 in normal breast tissue adjacent to breast carcinoma,but in breast carcinoma tissues,showing strongly positive expression.This suggested that the positive expression of p73 protein is related to the formation.And development of breast cancer. Conclusion YAP and p73 might be valuable markers in predicting early diagnosis,prognosis of breast cancer and molecule targets for therapy.The combined detection of the YAP and p73 might be a more appropriate method to identify the formation and development of breast cancer and to predict the prognosis of breast cancer.