Abstract: Abstract： ObjectiveTo observe the sensitivity of T-cell acute lymphoblastic leukemia (T-ALL) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and to discuss the possible mechanism. Methods 3 T-ALL cell lines and a primary cell were used and the expression of TRAIL receptors on the cell surface as well as the viability and apoptosis after incubation with TRAIL were measured. Results Most of the cell lines and the primary leukemia cell were highly resistant to TRAIL primarily owing to low cell-surface expression of death receptors. Conclusion Low expression of cellular surface death receptors might be one of the mechanisms for resistance to TRAIL-mediated cellular immunity.