Abstract: ObjectiveTo evaluate the efficacy and toxicity Compound tegafur capsule(S-1) plus Nedaplatin and Paclitaxel (SNP) regimen in the treatment of distant metastatic nasopharyngeal carcinoma. MethodsTwenty-one patients with distant metastatic nasopharyngeal carcinoma were enrolled and treated with S-1 capsule 80 mg/m2 twice daily for 14 days plus nedaplatin 80 mg/m2 and paclitaxel 135 mg/m2 by intravenous drip on d1. Treatment was administered every 3 weeks for 2~4 cycles. ResultsThe total effective rate was 71.4%. Three cases were complete response(14.3% ), 12 cases were partial response(57.1% ), 5 cases was stable disease (23.8%), 1 case were progressing disease (4.8%). The main adverse effect was myelosuppression,such as grade Ⅲ~Ⅳ neutropenia in 71.5% of all cases and grade Ⅱ~Ⅲ thrombocytopenia in 52.3% of all cases. Other adverse effects could be tolerated. ConclutionSNP regimen was a safe and effective therapy for patients with metastatic nasopharyngeal carcinoma although the long-term effects still need further evaluation.