XRCC1基因多态性与淋巴瘤发病风险的Meta分析
XRCC1 Polymorphisms and Lymphoma Risk:A Meta-analysis of Case-Control Studies
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摘要: 目的运用Meta分析的方法综合评价DNA修复基因（X-ray repair cross-complementing group 1,XRCC1)的多态性与淋巴瘤发病风险的关系。方法计算机检索PubMed、EMbase、中国期刊全文数据库、维普中文科技期刊数据库、中国生物医学文献数据库，同时手工检索所有纳入文献的参考文献，收集截止到2010年2月关于XRCC1基因多态性与淋巴瘤发病风险的病例对照研究，由两名研究者独立按照纳入标准筛选文献、提取资料并交叉核对，统计分析采用RevMan5.0软件进行。结果共纳入11个病例对照研究，包括4 569例患者和5 746例对照。Meta分析结果显示：XRCC1 codon 399 基因型Gln/Gln、Arg/Gln和Gln/Gln+Arg/Gln与野生型Arg/Arg相比，频率差异均无统计学意义（Gln/Gln vs. Arg/Arg:OR=1.04,95%CI［0.87,1.25］;Arg/Gln vs.Arg/Arg:OR=1.26,95%CI ［0.95,1.66］;Gln/Gln+Arg/Gln vs.Arg/Arg:OR=1.02,95%CI ［0.91,1.13］），Gln/Gln+Arg/Gln基因型则有可能增加霍奇金淋巴瘤的发病风险（OR=1.31,95%CI［1.02,1.69］），XRCC1 codon280和XRCC1 codon 194的基因多态性在患者和对照组之间的差异无统计学意义（XRCC1 codon280 His/His+Arg/His vs.Arg/Arg:OR=0.97,95%CI ［0.69,1.38］;XRCC1 codon 194 Trp/Trp+Arg/Trp vs.Arg/Arg:OR=1.01,95%CI［0.78,1.32］）。结论DNA修复基因XRCC1的基因多态性与非霍奇金淋巴瘤发病风险没有相关性，codon399位点的Gln/Gln+Arg/Gln基因型则有可能增加霍奇金淋巴瘤的发病风险。Abstract: ObjectiveTo evaluate the association between X-ray repair cross-complementing group1(XRCC1) gene polymorphisms and lymphoma risk by means of Meta-analysis. Methods We searched PubMed,EMbase,Chinese National Knowledge Infrastructure,China Journal Full Text Database,Chinese Biomedical Literature Database up to Feb 2010,the references of eligible studies were searched by hand.Case-Control studies involving X-ray repair cross-complementing group1(XRCC1) genetic polymorphism and lymphoma risk were included.Data were extracted independently by two reviewers according to designed extraction.The Cochrane Collaboration's RevMan 5.0 software was applied for statistical analyses. Results A total of 11 studies involving 4 569 patients and 5 746 controls were included.The results of Meta-analysis showed no statistical difference in the frequencies of variant genotypes and wild homozygote of XRCC1 between the Non-Hodgkin's lymphoma patients and controls,but Gln/Gln+Arg/Gln gentype of codon 399 may increase the risk of Hodgkin's lymphoma(OR=1.31,95%CI ［1.02,1.69］). Conclusion The polymorphism at codon 399,194 and 280 of XRCC1 are not associated with Non-Hodgkin's lymphoma risk but Gln/Gln+Arg/Gln genotype of codon 399 may increase the risk of Hodgkin,s lymphoma.
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