新辅助化疗对局部晚期非小细胞肺癌术后生存率的影响
Effect of Neo-adjuvant Chemotherapy with Surgery on Survival Ratio for Locally Advanced Non-small Cell Lung Cancer
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摘要: 目的探讨新辅助化疗对局部晚期非小细胞肺癌生存率的影响。方法可切除的局部晚期非小细胞肺癌119例；分两组：新辅助化疗+手术组（A组）59例，直接手术组(B组) 60例。对两组患者的临床资料进行统计学分析。结果 A组的总有效率为54.23%（32/59），病期下调率20.33%（12/59）；手术切除率和完全性切除率分别为91.5％和81.4％，高于对照组为81.7％和68.3％。两组患者术后1、3、5年生存率分别为79.66%、50.88%、21.43%和71.19%、35.09%、14.29%，两者比较差异有统计学意义(P<0.05)；术后平均生存时间分别为32.909月和28.046月，差异有统计学意义(P<0.05)，而术后并发症发生率两组比较差异无统计学意义(P>0.05)。结论新辅助化疗可显著提高局部晚期非小细胞肺癌的手术切除率，延长生存期，较直接手术组有优势，且未增加术后并发症，是安全可行的。Abstract: ObjectiveTo investigate the effect of Neo-adjuvant chemotherapy for locally advanced non -small cell lung cancer survival ratio. Methods 119 patients with locally advanced non-small cell lung cancer were divided into two groups:group A (59 cases,preoperative neoadjuvant chemotherapy group) and group B(control group 60 cases without neoadjuvant chemotherapy).Compared with the difference of survival rate，effective ratio and post-operation complication of the patients. Results The total effective rate of preoperative neoadjuvant chemotherapy group was 54.23%（32/59），down regulation rate of stage was 20.33%（12/59）.Resective rate and radical rate of experimental group was 91.5％ and 81.4％,high than control group.The 1-，3-，5-year survival rates were 79.66%，50.88%，21.43% in group A,and 71.19%，35.09%，14.29% in group B,there was statistically significant between the two groups(P<0.05).The average survival time was 32.909 months in group A and 28.046 months in group B,there was statistically significant between the two groups(P<0.05). Conclusion Compared with the first-operation group，neoadjuvant chemotherapy followed up surgery have advantages for locally advanced non-small cell lung cancer patients,it didn't add surgical complication and it is still safe and feasible.
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