Abstract: ObjectiveTo evaluate the efficacy and safety of cisplatin（PPD） plus interleukin-2（IL-2） to therapy malignant pleural effusion．MethodsSixty patients with malignant pleural effusion were divided into three groups：A group (n=23) injected by 40~60 mg of PPD and 1 000 000 units of IL-2，B group (n=19) injected with 60 mg PPD,C group (n=18) injected with 1 000 000 units of IL-2．The doses were given one time every week, for 2～ 3 weeks．The therapeutic effect and adverse reactions were observed after four weeks．ResultsThe total effective rates in the treatment group A,B and C were respectively 82.6％,68.4％ and 66.7％ respectively，and quality of life and KPS score improvement rate was 82.6%, 78.9%and 77.8%. Side effects were no significant difference among 3 groups. ConclusionPPD combined with IL-1 was efficacy and safety in the treatment of patients with malignant pleural effusions．