SFRP1和Wnt-1在宫颈鳞癌中的表达及意义

doi:10.3971/j.issn.1000-8578.2011.06.019

SFRP1和Wnt-1在宫颈鳞癌中的表达及意义

Expression and Significance of SFRP1 and Wnt-1 in Cervical Squamous Cell Carcinoma

摘要

摘要: 目的探讨SFRP1和Wnt-1在宫颈鳞癌中的表达及意义。方法采用免疫组织化学SP法检测SFRP1和Wnt-1蛋白在20例宫颈正常鳞状上皮、70例宫颈上皮内瘤变（cervical intraepithelial neoplasia，CIN）及50例宫颈鳞癌中的表达。结果（1）宫颈正常鳞状上皮、CINⅠ、CINⅡ/Ⅲ及宫颈鳞癌组织中，SFRP1阳性表达率分别是100%、73.5%、67.5%、34%（χ²=30.85，P<0.005)；Wnt-1的阳性表达率分别是25%、60%、82.5%、98%（χ²=45.57, P<0.005）。（2）SFRP1和Wnt-1在宫颈鳞癌中的表达无相关性（P>0.05）。（3）在宫颈鳞癌组织中，两者表达与患者的年龄、肿瘤大小、临床分期无相关性(P均>0.05)，而在不同组织分化程度间表达差异有统计学意义(P均<0.05)。结论SFRP1和Wnt-1参与了宫颈鳞状上皮的恶性转化过程，在由CIN发展到宫颈鳞癌的过程中起了促进作用。

Abstract: Abstract： ObjectiveTo explore the expression and significance of SFRP1 and Wnt-1 in cervical squamous cell carcinoma. MethodsSFRP1 and Wnt-1 were detected by immunohistochemistry(SP) in 20 cases of normal cervical squamous epithelium, 30 cases of CINⅠ,40 cases of CINⅡ/Ⅲ and 50 cases of cervical squamous cell carcinoma. Results(1)In normal cervical squamous epithelium, CINⅠ, CINⅡ/Ⅲ and cervical squamous cell carcinoma, the positive expression rate of SFRP1 were 100%, 73.5%, 67.5% and 34% respectively. The positive expression rate of Wnt-1 were 25%, 60%, 82.5% and 98% respectively. There was significantly different among four groups(P<0.05).(2)There was no correlation between SFRP1 and Wnt-1 in cervical squamous cell carcinoma.(3)In cervical squamous cell carcinoma group, there was no significant difference for SFRP1 and Wnt-1 expression in different age patient groups, and there was no difference among different tumor size, and clinical stages. However, there was significant difference among different pathological grades(P<0.05). ConclusionSFRP1 and Wnt-1 were related to the process of cancerating of cervical squamous epithelium, which maybe play important roles in the development from cervical intraepithelium neoplasis to invasive cervical squamous cell carcinoma.

HTML全文

参考文献(0)

施引文献

资源附件(0)