膀胱移行细胞癌血管生成拟态的实验

doi:10.3971/j.issn.1000-8578.2011.06.011

膀胱移行细胞癌血管生成拟态的实验

Experiment of Vasculogenic Mimicry in Transitional Cell Carcinoma of Bladder

摘要

摘要: 目的寻找在膀胱癌中是否存在血管生成拟态（VM），探讨VM的生物学意义。方法对85例膀胱移行细胞癌存档石蜡标本采用过碘酸雪夫氏反应（periodic acid schiff，PAS）和CD31双重染色，寻找血管生成拟态,分析VM存在的临床意义。结果在85例膀胱癌组织中有8例存在血管生成拟态，这些管道呈现PAS阳性、CD31阴性，其中2例为中分化膀胱癌，6例为低分化膀胱癌，包括T2期1例，T3期4例，T4期3例。8例中有6例出现淋巴结转移。VM存在与否与膀胱癌的病理分级、临床分期和淋巴结转移均有相关性（P<0.05）。结论中低分化膀胱癌中存在血管生成拟态，VM可作为判定膀胱癌恶性程度的一个指标和膀胱癌治疗的新靶向。

Abstract: ObjectiveTo search whether vasculogenic mimicry(VM) exists in transitional cell carcinoma of bladder(TCCB), and to explore the important biological significances of VM in TCCB. Methods85 TCCB specimens were collected and were stained with CD31, periodic acid schiff(PAS) and CK7, to observe that whether VM exists in this tumor or not. The cinical significance of VM in TCCB was assessed. ResultsPAS-positive pattern of VM were found in 8 TCCB specimens among 85 TCCB specimens. The 8 specimens belong to Ⅱ～Ⅲ grade and T2～T4 stage, 6 of them with lymphatic metastasis. VM correlated with clinic stage, histological grading and lymphatic metastasis (P<0.01). ConclusionOur results suggest that VM exists in some moderately /poorly differentiated TCCB; VM and EphA2 will be some good markers to monitor the malignant degree and some novel targets for therapeutic intervention against TCCB.

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