Abstract: ObjectiveTo evaluate the therapeutic efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) for the treatment on variceal bleeding due to portal hypertension（PHT）of patients with hepatocellular carcinoma(HCC)，and to evaluate factors for case selection for TIPS. Methods 48 patients with HCC complicated variceal bleeding due to portal hypertension performed TIPS were retrospected.Of the 48 patients, the average age was 50.8 years.Related information after TIPS, such as treatment success, complications, causes of death and so on, were assessed.The data of survival time of the 48 patients after treatment was collected by follow-up.The Kaplan-Meier method was used to conduct the survival analyses. Results TIPS was successful in 48 cases, the mean portal vein pressure was reduced about 10.6 mmHg (1mmHg=0.133kPa).After TIPS, variceal bleeding was controlled, the ascites and the clinical symptoms were relieved.According to the follow-up, incidence rate of hepatic encephalopathy complicated with TIPS was 18.8% and rebleeding was 27.0%.The median survival time of the patients was about 5.0 months, and it shortened from Child-Pugh class A to C. Conclusion TIPS is one of effective and safe therapeutic methods to control variceal bleeding due to portal hypertension of patients with HCC.However, liver function is an important factor for case selection for TIPS.