Abstract: ObjectiveTo explore the relationship of angiopoietins (Angs) with multiple myeloma(MM) and its clinical significance. Methods The serum concentration of Angs in different periods was detected by double-antibody sandwich enzyme-linked immunosorbent assays technique in 60 cases of MM patients and 20 controls.The associations between the serum cytokines levels with MM stages(Ⅱ～ Ⅲ), tumor load and the curative effect were observed,respectively. Results Pretreatment MM had significantly higher serum Ang-2 levels than controls.Serum Ang-1 levels in pretreatment MM had no significant difference compared with controls.Pretreatment serum Ang -2 levels were significantly lower in stage Ⅱ than in stage Ⅲ of MM.There weas significant difference between the different tumor load.In the patients responding to chemotherapy,Ang-2 serum levels was significantly decreased, while serum Ang-1 levels was no significant difference. In the patients who did not achieve a remission, there was no significantly change in serum Ang-1 levels and serum Ang-2 levels. Conclusion Serum levels of Ang-2 detection in MM patients is a certain extent significance to study of the pathogenesis of MM, the condition evaluation, efficacy monitoring, and outcome of prediction.