Abstract: ObjectiveTo evaluate the effect and toxic reaction of three dimensional conformable radiotherapy （3D-CRT)after whole pelvic radiotherapy with concurrent chemoradiotherapy on middle and advanced cervical cancer. MethodsSixty-two patients with middle or advanced cervical cancer were divided randomly into 3D-CRT after whole pelvic radiotherapy with concurrent chemoradiotherapy（A group）and afterloading irradiation after whole pelvic radiotherapy with concurrent chemoradiotherapy(B group). After receiving 36～40Gy /20 fractions of external radiation to the whole pelvic, patients in the group A were irradiated by 3-DCRT with the total dose of 66～75Gy. Patients in the group B received 45～50Gy external radiation to the parametrrium, and point A received 30Gy by after loading irradiation （4～7Gy per-fraction,1～2 fractions per week）. All patients were given concurrent chemoradiotherapy in the firstweek and the fourth week. ResultsEffective rate was 96.88% in group A and 76.67% in group B(P<0.05).The rates of bone marrow inhibition and long-term complication for the rectum and bladder were significantly lower in group A than in group B(P<0.05). Conclusion The 3D-CRT after whole pelvic radio-therapy with concurrent chemoradiotherapy for middle and advanced cervical cancer could improve local control rate.