Abstract:
ObjectiveTo investigate the correlation between mRNA expression of PDGF-D and PDGFRβ and clinicopathological features in gastric cancer. Methods The reverse transcription-polymerase chain reaction(RT-PCR)technique was used to examine mRNA expression of PDGF-D and PDGFRβ in 58 paired specimens of gastric carcinoma and tissues adjacent carcinoma. Results The positive rates of PDGF-D mRNA and PDGFRβ mRNA(98.28%,87.93%)were higher in gastric cancer tissues than(72.41%,53.45%)in tissues adjacent carcinoma respectively. While the positive rate of PDGFRβmRNA was 72.41%,which was positively correlated with PDGF-D(
r=0.40,
P<0.05).PDGF-D expression was correlated with lymph node metastasis and relapse (
P<0.05).No correlation was found between PDGF-D and other clinicopathological features of gastric carcinoma(
P>0.05). Conclusion PDGF-D may play a crucial role in carcinogenesis,development,metastasis and relapse of gastric cancer. It can be used as prognostic markers of gastric cancer in clinical practice.