Abstract: Abstract:Objective To study the expression of p27 and MCM7 protein in endometrioid carcinoma and its clinical significance. Methods The expression of p27 and MCM7 proteins were tested by SP immunohistochemistry from normal endometrium（30 cases）, endometrial hyperplasia（30 cases）, atypical hyperplasia（30 cases） and endometrioid carcinoma（50 cases）. Results The positive expression of p27 decreased gradually in different groups： normal endometrium ＞endometrial hyperplasia ＞endometrial dysplasia ＞endometrioid carcinoma. There was a significant difference amory these groups （P<0.05）. But the positive expression of MCM7 in four groups showed an increased gradually. The expression of MCM7 in endometrioid carcinoma and endometrial dysplasia groups were significently higher than those in normal endometrium and endometrial hyperplasia groups（P<0.05）.Negative correlation was found between the expression of p27 and MCM7 （r=-0.3306，P<0.02）. In endometrioid carcinoma group, the lower expression of p27 protein was significantly associated with histological grading（P<0.05）and pathologic stage(P<0.05). The overexpression of MCM7 protein was significantly correlated with histological grading, myometrial invasion, lymph node metastasis and pathologic stage （P<0.05）,respectively.The lower expression of p27 and higher expression of MCM7 were related with recurrence in endometrioid carcinoma（P<0.05）. Conclusion The results suggest that the low expression of p27 and the overexpression of MCM7 protein may be involved in carcinogenesis and development of medometrioid carcinoma. Combined examining of p27 and MCM7 protein may be used as a biomarker in the early diagnosis and for the prognosis judgement of endometrioid carcinoma.