Abstract: Abstract: Objective To study the effect of rotary magnetic field (RMF) combining 5-Fu on the cycle and apoptosis of mouse cell line SP2/0 in vitro. Methods SP2/0 cells were randomly divided into four groups: control group (N), 5-Fu group (C), magnetic group (M) and magnetic combining 5-Fu group (M+C).The M and M+C groups were treated with a RMF for two hours once a day.On day 4, the C and M+C groups were treated with 5-Fu 20 μg/ml.On day 5, cell cycle and apoptosis were measured by the flow cytometric (FCM). Results The S phase proportion of the M group and the G1 phase proportion of the C group were higher than that of the other three groups（P<0.05）.The S phase proportion of the M+C group decreased and lower than that of the M group，but was still higher than that of the N and C groups（P<0.05）.There was no significant difference in apoptosis rates between the N and M groups（P>0.05）.The apoptosis rates of the C and M+C groups were remarkedly higher than those of the N and M groups and the M+C group had the highest apoptosis rate. Conclusion The RMF can't induce the apoptosis.But it can enhance the cytotoxicity of 5-Fu and promote the cell apoptosis.The mechanism of the apoptosis may be related to SP2/0 cell line arrested at S phase.Abstract:Objective To investigate the clinicopathologic features, immunological phenotype and differential diagnosis of serous microcystic adenoma of the pancreas (SMAP). Methods Three cases of SMAP were analyzed by light microscopy and immunohistochemistry; and related literature was reviewed. Results SMAP manifested as abdominal pain accompanied with unexplained emaciation.In microscopy, SMAP were composed of multiple small cysts lined by cuboidal or flattened epithelial cells.The cytoplasm of these cells was clear, and the nucleus was in the center.Immunophenotype results shown that the cavosurface endothelial cells were positive for EMA and CK19, partly positive for CA19-9, less than 2% of these cells were positive for Ki67, and were negative for CEA, CgA, Syn, S-100, Vimentin and Ⅷ factor. Conclusion SMAP, as one tumor occurred predominantly in elder females, was a rare benign tumor and the conclusiye diagnosis was depended on the pathology examination.However, sometimes, it needed the immunohistochemical helps to differentiate from other pancreatic tumors.Moreover, it sometimes needed a long term follow-up in order to decide the nonmalignant or malignant diagnosis of the tumor.