HDAC6在胃癌组织中的表达及意义
Expression and Significance of Histone Deacetylase 6(HDAC6)in Gastric Cancer Tissue
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摘要: 目的 检测胃癌及胃良性病变组织中组蛋白去乙酰化酶6（HDAC6）的表达及其与胃癌的发生及各种临床病理因素之间的关系。方法 采用免疫组织化学方法，检测40例胃癌组织及36例胃良性病变组织中HDAC6的表达，分析其与临床病理因素间的关系。结果 在40例胃癌组织中HDAC6呈高表达的有25例，而在36例胃良性病变组织中呈高表达的仅有10例，两者相比差异均有统计学意义（χ2=9.915，P=0.003）。HDAC6在胃癌组织中的表达与分化程度（χ2=7.116，P=0.022）、临床分期有相关性（rs=0.442，P=0.001），相反，HDAC6的表达和其他的临床病理因素无关，如年龄、性别、浸润深度、淋巴结转移。结论 HDAC6在胃癌组织中呈过表达状态，其表达水平可以作为判断胃癌患者恶性程度的一个潜在指标，也可以作为一个预后指标。Abstract: Objective To investigate the expression and its clinical significance of histone deacetylase 6 in gastric cancer tissue and gastric benign lesion．Methods The expression of HDAC6 in 40 cases of surgically respected gastric cancer tissues and 36 cases gastric benign lesion were detected by ICH．Results The expression level of HDAC6 protein in the gastric carcinoma tissue was related to tumor clinical stage and cell differentiation，whereas was not related to age，gender soakage deepness，metastasis Conclusion The expression level of HDAC6 protein is presumed to be a indicator of malignancy degree and prognosis.
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