非小细胞肺癌组织中雌激素受体β和Ki-67、Bax表达的相关性

doi:10.3971/j.issn.1000-8578.2010.08.013

非小细胞肺癌组织中雌激素受体β和Ki-67、Bax表达的相关性

Expression of Estrogen Receptor β in Human Non-small Cell Lung Cancer and Its Correlation with Expression of Ki-67 and Bax

摘要

摘要: 目的：探讨NSCLC组织中ERβ和增殖相关蛋白Ki-67、凋亡相关蛋白Bax表达的相关性。方法采用免疫组织化学SABC法检测ERβ、Ki-67、Bax在49例NSCLC和14例良性肺病变组织中的表达，分析其表达的相关性。结果：ERβ在NSCLC中的表达率为36.7%，而在肺良性病变组织中无表达（P=0.019）。在NSCLC中，ERβ阳性组Ki-67的表达率(83.3%)显著高于ERβ阴性组 (51.6%)（P=0.004），ERβ与Ki-67的表达呈正向相关；ERβ阳性组Bax的表达率(38.9%)与ER β阴性组(51.6%)的差异无统计学意义（P=0.442），ERβ与Bax的表达无相关性。结论：ERβ在NSCLC中过表达，与Ki-67表达呈正相关，与Bax的表达无相关性，ERβ可能有促进NSCLC增殖的作用。

Abstract: Objective：To explore the role ERβ in cell proliferation and apoptosis and investigate the expression of ERβ in NSCLC and its correlation with the expression of ki-67 and Bax. Methods：The expression of ERβ, Ki-67 and Bax in 49 specimens from patients with lung cancer and 14 specimens from patients with benign lung diseases was investigated by immunohistochemistry. The correlation between ERβ and Ki-67, Bax was analyzed. Results：The positive ratio of ERβ expression in NSCLC was 36.7%, whereas no clear staining was found in benign lung tissues (P=0.019). The expression of Ki-67 in ERβ positive group was significantly higher than that in ERβ negative group of NSCLC(P=0.004). There was no significant difference between the expression of Bax in ERβ positive group and ERβ negative group (P=0.442). Conclusion：ERβ is overexpressed in NSCLC and has a positive correlation with cell proliferation-associated protein Ki-67.ERβ may promote the proliferation of NSCLC.

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